肠道微生物群结构和新陈代谢功能的综合分析,用于肝硬化和耐火性炎患者
Dianyan Chen1, Sandu Liu1, Ka Zhang2
1Department of Hepatology, The People's Hospital of Qiannan, Duyun, Guizhou 558000, P.R. China.
Biomedical reports
|January 21, 2026
概括
耐火性炎患者表现出显著的肠道微生物和代谢变化,包括减少多样性和改变代谢物概况. 这些肠道变化可能为肠肝轴和肝硬化并发症的潜在生物标志物提供了洞察力.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 耐火性炎是不补偿性肝硬化症的严重并发症.
- 耐火性炎的肠道微生物和代谢场景尚未完全理解.
研究的目的:
- 为了研究肠道微生物的组成和代谢物概况在耐火性炎的患者.
- 为了确定与耐火性炎相关的潜在微生物和代谢生物标志物.
主要方法:
- 结合16S rRNA测序和非目标代谢学.
- 分析了肠道微生物群的多样性,分类学和功能.
- 选和映射改变的代谢物及其疾病关联.
主要成果:
- 耐火性炎患者表现出肠道微生物α多样性减少和明显的β多样性模式.
- 观察到蛋白质细菌和特定的Firmicutes属 (例如,Clostridium,Lactobacillus) 的丰富.
- 鉴定了2890种改变的代谢物,其中包括神经质突触和类固醇激素生物合成等途径.
- 选择的代谢物表现出耐火性炎的高分辨性能 (>0.93 AUC).
结论:
- 耐火性炎与肠道微生物群和新陈代谢的显著结构和功能变化有关.
- 研究结果提供了关于肝硬化中肠肝轴的见解.
- 确定了耐火性炎的潜在微生物和代谢生物标志物.
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