在后COVID-19综合征中循环血管原始细胞亡
Julia M Kröpfl1, Christoph Hauser1, Luca Beugger1
1Division of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Grosse Allee 6, 4052 Basel, Switzerland.
患有COVID-19后持续症状的患者可能有循环血管原生细胞 (CAC) 和成熟内皮细胞 (CEC) 的水平发生变化,这表明感染后很长一段时间内可能存在细胞内皮功能障碍.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 传染病流行病学 传染病流行病学
背景情况:
- 在COVID-19住院后的持续症状 (PH-PCS) 是常见的.
- 细胞内皮功能障碍是PH-PCS的一个鲜为人知的并发症.
- 这项研究研究了长期出现COVID-19后症状的个体的内皮细胞群.
研究的目的:
- 在PH-PCS患者和对照者之间比较循环血管原生细胞 (CAC) 和成熟内皮细胞 (CEC).
- 评估PH-PCS患者的宏观和微血管结构和功能.
- 探索长期COVID中内皮细胞变化和血管功能之间的潜在联系.
主要方法:
- 流细胞计用于分析CAC和CEC群体.
- 通过手臂动脉流介导扩张 (baFMD) 评估了宏血管功能.
- 通过视网膜血管成像和最大动脉狭窄测量来评估微血管功能.
主要成果:
- 患有PH-PCS的患者表现出较低度和尾性CAC和CEC的比例的趋势.
- 相反,在PH-PCS中,活体CAC和CEC的比例有所提高.
- 虽然大多数血管功能测试没有显示出显著差异,但PH-PCS中最大动脉管收缩率更高,尽管不确定.
- 降低baFMD与增加的总CEC和降低的亡性CAC比例相关.
结论:
- 这项研究表明,PH-PCS患者的CAC和CEC亡中存在潜在的不平衡.
- 研究结果表明,尽管不确定,但在COVID-19后很长一段时间内细胞内皮功能可能发生变化.
- 结果可能会指导未来对长期COVID中的内皮功能障碍的研究.
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