在综合征和非综合征性动脉动脉病症中,自主和巴罗反射规则:一个病例控制研究
Beatrice Cairo1, Nathasha Samali Udugampolage2, Francesca Gelpi1,3
1Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Frontiers in physiology
|January 21, 2026
概括
静止时胸前大动脉动脉瘤 (TAA) 患者的巴罗反射灵敏度 (BRS) 降低,这表明由于大动脉机械变化而改变了自主控制. 综合征和非综合征TAA组显示了类似的BRS修改.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统功能 自主神经系统功能
- 大动脉疾病研究研究
背景情况:
- 鼓膜反射调节依赖于机械敏感的鼓膜受体,其功能可能会受到大动脉特性的影响.
- 胸前大动脉动脉瘤 (TAA) 改变了大动脉的机械和尺寸特征.
- 以前的研究表明,TAA患者的巴罗反射灵敏度 (BRS) 可能会发生变化.
研究的目的:
- 在患有综合征 (Synd) 和非综合征 (NonSynd) TAA的患者中评估和比较自主控制和BRS.
- 研究Synd和NonSyndTAA亚组之间的自主和巴罗反射功能的潜在差异.
- 为了比较TAA患者的自主和巴罗反射功能,与年龄和性别匹配的健康对照 (HCs) 进行比较.
主要方法:
- 80名TAA患者被招募并分为Synd (N=46) 和NonSynd (N=34) 组.
- 在低频 (LF) 和高频 (HF) 频段中,使用心脏周期 (HP) 和静脉压 (SAP) 的变化来评估自主功能和BRS.
- 在休息的仰卧和活动的站立条件下,TAA子组和28个年龄和性别匹配的HC进行了比较.
主要成果:
- 在Synd和NonSyndTAA子组之间没有发现自主控制或BRS的显著差异.
- 在LF频段的BRS在TAA患者中明显低于休息期间的HC患者.
- 活动站立减少了HF频段和LF频段BRS中的HP变异性,同时增加了HC和TAA患者的LF频段SAP变异性.
结论:
- 在休息的TAA患者中,BRS受损,可能是由于与病理学相关的大动脉机械或维度特性发生变化.
- 在BRS中观察到的修改在综合征和非综合征TAA组中一致.
- 在TAA患者和健康对照者之间,对姿势变化 (活动站立) 的自主反应类似.
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