食补充剂对雄激素脱发症的影响:系统性审查和网络元分析
Lei Zhou1, Wenkang Zhu2, Yan Chen1
1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in nutrition
|January 21, 2026
概括
食补充剂有望改善发密度和终端发密度在雄原性脱发症 (AGA) 患者. 这些补充剂耐受性很好,可以作为传统治疗的替代方案.
科学领域:
- 皮肤病学 皮肤病学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 雄激素性脱发症 (AGA) 是一种普遍的疾病,导致脱发和心理困扰.
- 像费纳斯特和米诺克西迪尔这样的传统治疗方法存在局限性,需要探索更安全的替代方案.
- 食补充剂越来越多地用于AGA,这是由于感知到的安全性和可访问性.
研究的目的:
- 进行网络元分析 (NMA),比较各种食补充剂治疗AGA的疗效和安全性.
- 为临床决策提供基于证据的支持,以在AGA管理中使用补充剂.
主要方法:
- 在主要的英语数据库中对随机对照试验 (RCT) 进行系统搜索.
- 使用Stata 16.0软件进行的网络元分析 (NMA).
- 使用Revman 5.4和GRADE框架评估研究质量和偏差风险.
主要成果:
- 有1658名患者的19个RCT研究了16种不同的食补充剂.
- 一些补充剂,包括标准化植物提取物 (Nutrafol) 和南瓜油 (PSO),与安慰剂相比,显著改善了头发密度.
- 多成分补充剂,Nutrafol和益生菌增加了终端头发密度,而PSO,素-异黄 (CI) 和其他在盲人医生评估中显示出积极的结果. 所有的补充剂都被很好地容忍.
结论:
- 食补充剂对AGA患者的头发密度,终端头发密度和临床评估产生积极影响.
- 这些补充剂表现出良好的耐受性和作为常规AGA治疗的辅助或替代品的潜力.
- 建议进一步进行大规模,高质量的RCT来验证这些发现.
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