针治疗高排泄性化疗引起的恶心和吐:系统性审查和元分析
Run Lin1, Zining Guo2, Jiewen Zhang2
1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in neurology
|January 21, 2026
概括
针可以帮助控制化疗引起的恶心和吐 (CINV). 然而,大多数研究都有很高的偏见,证据质量通常很低,需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 综合医学是一个整体的医学.
- 基于证据的实践.
背景情况:
- 化疗诱导的恶心和吐 (CINV) 是接受高排泄性化疗 (HEC) 的患者面临的重大挑战.
- 针已经成为管理CINV的潜在补充疗法.
- 关于针对HEC诱导的CINV有效性的现有证据需要全面评估,因为确定性不清楚.
研究的目的:
- 系统地评估针在治疗化学疗法诱导的恶心和吐 (CINV) 的有效性和证据质量,在接受高排泄性化学疗法 (HEC) 的患者中.
- 评估不同类型的针对CINV控制的影响.
主要方法:
- 进行了对58项随机对照试验 (RCT) 的系统审查和元分析.
- 数据库从创建开始到2024年12月进行了搜索. 偏差风险使用Cochrane ROB 2.0进行评估,证据质量使用GRADE系统进行评分.
- 根据针类型和出版偏差评估进行了子组分析.
主要成果:
- 针在急性和延迟阶段 (总体RR 1.54,延迟RR 1.56) 显著改善了CINV的完全控制率.
- 虽然在吐方面有效,但针在缓解恶心症状方面表现不确定. 不同的针类型表现出不同的优势.
- 大多数纳入的研究都表现出高偏差风险,导致方法质量低下. 证据质量主要是低或非常低,除了急性吐持续时间 (中等质量).
结论:
- 针证明了对管理高度发泄性化疗诱导的恶心和吐的潜在益处.
- 包括高偏差风险和低质量证据在内的局限性需要谨慎.
- 进一步进行高质量的随机对照试验至关重要,以确定针对HEC诱导的CINV的疗效.
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