胎儿MRI上的Sylvian裂角度发展:怀孕22-38周
Yan Song1, Siyan Lu1, Hongyu Yin1
1Department of Radiology, Sichuan Provincial Woman's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Frontiers in neuroscience
|January 21, 2026
概括
使用MRI量化胎儿的Sylvian裂角 (SFA) 发育,建立参考范围和生长曲线. 这有助于准确的胎儿大脑评估和识别潜在的皮质形.
科学领域:
- 神经成像是一种神经成像.
- 胎儿的发育 胎儿的发育
- 定量解剖学 定量解剖学
背景情况:
- 西尔维亚裂 (SF) 是胎儿大脑发育的一个关键里程碑.
- 精确量化SF发展对于评估神经发育异常至关重要.
研究的目的:
- 在怀孕期间使用胎儿MRI量化西尔维亚裂角 (SFA) 发育.
- 为SFAs建立规范性参考范围和增长曲线.
- 提供一个定量框架,用于检测皮质形的指示性偏差.
主要方法:
- 追溯分析324个胎儿的MRI (怀孕22-38周).
- 在轴和冠状平面上测量六个SFAs (SFPA,SFARA,SFPRA,SFSRA,SFIRA).
- 与妊娠年龄和生长曲线建模的相关性分析.
- 使用回顾性皮质形病例进行验证.
主要成果:
- 在SFA测量中具有很高的观察者间可靠性 (ICC 0.772-0.976).
- 在SFARA,SFSRA和妊娠年龄之间存在显著的积极关联.
- 在SFPRA,SFIRA,SFPA和妊娠年龄之间存在显著的负面关联.
- 二次式增长曲线模型表明,最适合SFA发展.
- 该模型成功地发现了皮质形.
结论:
- 胎儿MRI有效评估动态的SFA发育.
- 确立的SFA参考范围提高了胎儿大脑评估的准确性.
- 提供了一种定量工具,用于识别暗示皮质形的偏差.
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