质子束疗法作为复发性子宫内膜癌的有效治疗选择
Yuta Endo1,2, Yoshiaki Takagawa3,4,5, Yuki Yoshimoto1
1Department of Gynecology, Southern TOHOKU General Hospital, Fukushima, Japan.
Gynecologic oncology reports
|January 21, 2026
概括
质子束疗法 (PBT) 是对复发性子宫内膜癌 (REC) 的安全有效治疗方法. 较小的瘤 (<22.5毫米) 显示出更好的局部控制,表明PBT.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 妇科瘤学 妇科瘤学
背景情况:
- 再发性子宫内膜癌 (REC) 是一个重大的临床挑战.
- 对REC的救援治疗选择有限,需要新的治疗方法.
研究的目的:
- 评估质子束疗法 (PBT) 对复发性子宫内膜癌患者的疗效和安全性.
- 为了确定与REC中PBT后的局部控制 (LC) 相关的预后因素.
主要方法:
- 在2008年至2021年期间接受PBT治疗的REC患者的回顾性分析.
- 卡普兰-梅尔方法用于估计LC,无进展生存期 (PFS) 和整体生存期 (OS).
- 使用CTCAE v5.0标准进行毒性评估.
主要成果:
- 总共有9名患有14种病变的患者被分析 (随访时间中位数:36.4个月).
- 一年和两年的LC率分别为80.2%和68.8%.
- 瘤大小<22.5毫米是高级LC的显著预测因素;没有观察到≥3级毒性.
结论:
- 质子束疗法 (PBT) 似乎是复发性子宫内膜癌的安全有效的救援治疗方法.
- PBT为REC提供了一个可行的选择,特别是在涉及较小瘤体积的情况下.
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