巩固性质子疗法对儿科古典霍奇金淋巴瘤的长期结果
Daniela Martir-Vargas1, Daniel J Indelicato1, Allison Bechtel2
1Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL, USA.
International journal of particle therapy
|January 21, 2026
概括
巩固性质子疗法 (cPT) 显示了儿童经典霍奇金淋巴瘤 (cHL) 的优异的10年生存率和无复发率,即使在复发的情况下. 这种方法尽量减少晚期影响,支持在年轻患者中使用它.
科学领域:
- 儿科瘤学 儿科瘤学
- 辐射瘤学 辐射瘤学
- 血液学恶性瘤 血液学恶性瘤
背景情况:
- 经典霍奇金淋巴瘤 (cHL) 通常具有良好的预后和高生存率.
- 巩固性质子疗法 (cPT) 是青少年患者的偏好,以减少辐射退出剂量,并最大限度地减少长期副作用.
研究的目的:
- 评估使用cPT治疗cHL的儿科患者的结局.
- 评估cPT在新诊断和复发/耐药 (R/R) cHL病例中的疗效和安全性.
主要方法:
- 74名患有cHL的儿科患者 (6至22岁) 的回顾性分析,这些患者接受了cPT后系统治疗.
- 基于系统治疗的风险分层 (低,中等,高).
- 卡普兰-梅尔总生存时间 (OS) 和无复发生存时间 (RFS) 估计方法.
主要成果:
- 随访时间的中位数为5.5年,10年的生存率为96% (97%初始,92%R/R) 和10年的RFS为84% (82%初始,92%R/R).
- 根据风险组的10年RFS不同:100% (低),82% (中等),72% (高).
- 观察到复发率低,只有一个3级+晚期毒性 (乳头甲状腺癌).
结论:
- cPT是一种有效且耐受良好的儿科cHL治疗方法.
- 通过cPT可以获得优异的长期结果 (OS和RFS),包括R/R疾病.
- 需要进一步的研究来证实长期的结果,并支持cPT作为标准模式.
相关概念视频
Classical Conditioning
2.1K
Associative learning, a core principle in behavioral psychology, involves forming connections between events and facilitating learned responses. This concept is vividly illustrated by classical conditioning, a process extensively studied by the Russian physiologist Ivan Pavlov. Pavlov's pioneering research on dogs' digestive systems led to the discovery that behaviors can be learned through association, laying the groundwork for classical conditioning.
Ivan Pavlov observed that dogs...
Ivan Pavlov observed that dogs...
2.1K
Principles of Classical Conditioning
1.8K
Classical conditioning, as described by Ivan Pavlov, is a foundational concept in associative learning, where a neutral stimulus becomes capable of eliciting a conditioned response through association with an unconditioned stimulus. The process of acquisition, where this learning occurs, and the subsequent phenomena of contiguity, contingency, generalization, discrimination, extinction, and spontaneous recovery are crucial for a comprehensive understanding of classical conditioning.
During the...
During the...
1.8K
Predicting Reaction Outcomes
10.3K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.3K
Classical Conditioning in Daily Life
2.1K
Classical conditioning, a fundamental principle of associative learning, explains various phenomena observed in daily life, such as fear development, the placebo effect, taste aversion, and drug habituation. These applications demonstrate the profound impact of associative learning on human behavior and physiological responses.
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...
2.1K
Real-World Application of Classical Conditioning
1.3K
Classical conditioning not only includes the initial pairing of stimuli but also extends to more complex forms, such as higher-order conditioning. Higher-order conditioning involves creating associations beyond the primary conditioned stimulus, resulting in a chain of conditioned responses.
Higher-order, or second-order, conditioning occurs when a neutral stimulus becomes associated with an already established conditioned stimulus through repeated pairings. For instance, if a dog has been...
Higher-order, or second-order, conditioning occurs when a neutral stimulus becomes associated with an already established conditioned stimulus through repeated pairings. For instance, if a dog has been...
1.3K
Outcomes of Glycolysis
106.8K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
106.8K


