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OX40/OX40L:瘤免疫疗法的新目标及其临床研究进展

Zixuan Yuan¹, Yutong Pan¹, Haodong Yuan¹

¹School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.

Frontiers in oncology

|January 21, 2026

概括

OX40-OX40L通路通过增强T细胞反应来增强抗瘤免疫力. 然而,单独使用OX40激动剂的疗效有限,因此需要结合策略来改善癌症治疗.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

瘤坏死因子受体超级家族 (TNFRSF) 包括免疫反应的关键调节者.
TNFRSF4 (OX40) -TNFSF4 (OX40L) 轴是T细胞激活和抗瘤免疫的关键辅助刺激途径.
OX40激动剂增强T细胞增殖,生存和细胞因子分泌,同时抑制调节性T细胞.

研究的目的:

评估OX40激动剂单疗在癌症治疗中的疗效和局限性.
确定阻碍OX40激动剂有效性的机械瓶.
探索优化基于OX40的免疫疗法的策略.

主要方法:

对OX40agonist单独治疗和组合治疗的临床试验数据的审查.
对限制T细胞反应的机制因素的分析.
评估与联合免疫疗法相关的免疫相关不良事件.

主要成果:

与PD-1抑制剂相比,OX40激素单一治疗耐受性良好,但客观响应率较低.
关键的局限性包括OX40激动剂亲和力不足,T细胞透率差,和持续的调节性T细胞.
组合疗法 (例如,使用PD-1抑制剂,放射治疗,化疗) 改善了反应率,但增加了严重的免疫相关不良事件.

结论:

需要具有高亲和力和瘤特异激活的新型OX40激动剂.
在组合疗法中将OX40激动剂作为辅助疗法可以平衡疗效和安全性.
优化基于OX40的免疫疗法需要解决当前的机制限制,并仔细管理不良事件.

关键词:

在OX40中,OX40是什么?这是一种OX40激动剂.在OX40L中.有针对性的治疗.瘤免疫力免疫力

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