在腺损伤中,叶片特异性恶性病的风险:基于米兰系统的分析
Serkan Şerifler1, Fatih Gül2, Ali Öztürk3
1Department of Otolaryngology, Head and Neck Surgery, School of Medicine Ankara Yıldırım Beyazıt University Ankara Turkey.
Laryngoscope investigative otolaryngology
|January 21, 2026
概括
精细针吸收细胞学 (FNAC) 准确地使用米兰系统诊断膜病变. 然而,与表面病变相比,深叶膜病变的恶性瘤风险明显更高.
科学领域:
- 头和部病理学 头部和部病理学
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
背景情况:
- 腺病变需要准确的诊断来进行适当的管理.
- 精细针吸收细胞学 (FNAC) 是一个关键的诊断工具.
- 米兰唾液腺细胞病理学系统标准化了报告.
研究的目的:
- 用米兰系统评估FNAC用于膜病变的诊断准确性.
- 消除诊断准确性评估中的验证偏见.
- 为了在米兰类别中比较表面和深叶膜病变之间的恶性瘤 (ROM) 风险.
主要方法:
- 对332名患者进行超声导向FNAC和随后的外科切除 (2019-2025) 的回顾性审查.
- 根据米兰系统对FNAC结果的分类.
- 计算ROM和诊断性能指标,根据叶片位置进行子组分析. 确保进行完整的组织病理学验证.
主要成果:
- 在11.1%的病例中确诊恶性病变,在深叶 (24.6%) 与表面叶 (7.9%) 病变的频率明显高 (p<0.001),风险增加了3.1倍.
- 在大多数米兰类别中,深叶病变显示出更高的ROM,包括"良性瘤"类别中增加7.3倍的风险 (7.3%对1.0%,p=0.009).
- 高风险类别 (可疑/恶性) 具有相似的ROM,无论其解剖位置如何.
结论:
- 当使用米兰系统进行分类时,FNAC为膜病变提供了可靠的诊断性能.
- 解剖位置是影响恶性瘤风险的关键因素.
- 深叶膜病变在各种诊断类别中存在明显更高的恶性瘤风险.
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