传递方式与注意力缺陷多动障碍之间的关系:元分析和系统审查
Jiali Wei1, Zehao Zheng1, Yao Zheng2
1Beijing University of Chinese Medicine, Beijing, China.
PeerJ
|January 21, 2026
概括
剖腹产 (剖腹产) 与儿童注意力缺陷多动症 (ADHD) 风险中适度增加有关. 在多项研究中观察到这种关联,突出了对神经发育结果的潜在担忧.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科健康 儿科健康
- 产科和妇科 产科和妇科
背景情况:
- 注意缺陷多动性障碍 (ADHD) 是一种常见的儿童神经发育障碍,原因不明.
- 新兴研究表明,剖腹产 (C-section) 交付与ADHD风险增加之间存在潜在联系.
- 导致ADHD的病因因素需要进一步研究.
研究的目的:
- 调查剖腹产分娩与儿童患ADHD风险之间的关联.
- 使用元分析技术,综合观察性研究的证据.
- 提供关于剖腹产分娩和ADHD风险的当前研究的全面概述.
主要方法:
- 在主要数据库 (PubMed, Web of Science, CNKI, Wanfang, VIP) 进行了系统的文献搜索.
- 包括的研究是观察性 (病例控制或队列),具有标准化的ADHD诊断和可提取的效果估计.
- 使用R Studio提取和分析数据,将调整的赔率比率 (ORs) 与95%的置信区间 (CI) 结合起来. 研究质量使用纽卡斯尔-太华尺度 (NOS) 进行评估.
主要成果:
- 包括来自10个国家的14项研究 (6个病例控制,8个队列).
- 综合调整的ADHD风险OR为1.44 (95%CI [1.04-1.25]) 在病例控制研究和1.12 (95%CI [1.10-1.15]) 在队列研究中.
- 大多数研究调整了诸如母亲年龄,孩子的性别和妊娠因素等混因素;所有研究都达到最低质量评分.
结论:
- 剖腹产与儿童中ADHD风险中适度增加有关.
- 选择性和紧急剖腹产都显示了与ADHD风险的类似关联.
- 需要进一步的研究来阐明这种关联的因果路径和生物学机制,承认研究异质性和潜在的偏见.
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