患有SARS-CoV-2感染的患者的肺移植:一个病例报告
Elena Seminari1, Paola Giordani1, Patrizia Cambieri2
1Department of Infectious Diseases - Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Respiratory medicine case reports
|January 21, 2026
概括
这项研究报告了在患有活跃COVID-19感染的患者中成功进行双肺移植的情况. 患者在没有患上COVID-19肺炎的情况下康复良好,证明了SARS-CoV-2感染期间肺移植的安全性.
科学领域:
- 移植医学 移植医学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 随着COVID-19大流行,人们对来自捐赠者的感染和免疫抑制的移植受体的严重结果产生了担忧.
- 移植协会建议在患有活跃SARS-CoV-2感染的患者中不进行移植,因为严重疾病的风险增加.
- 有限的数据存在于SARS-CoV-2阳性接受者的固体器官移植,特别是肺移植.
研究的目的:
- 在患有活跃SARS-CoV-2感染的患者中成功进行双肺移植的案例.
- 评估SARS-CoV-2阳性接受者肺移植的安全性和结果,具有低周期值 (CT) 值.
主要方法:
- 在手术当天,对一个阳性SARS-CoV-2分子拭子 (低CT值) 的患者进行了双肺移植.
- 患者在术后接受了雷梅西维尔治疗.
- 移植后的结果,包括肺功能和COVID-19状态,都受到密切监测.
主要成果:
- 双肺移植是成功的,患者在手术后的第三天被抽管.
- 患者实现了良好的肺功能,并迅速清除了SARS-CoV-2RNA,没有COVID-19相关的并发症.
- 尽管免疫抑制,患者没有发展SARS-CoV-2肺炎.
结论:
- 肺移植可以安全地在选择的SARS-CoV-2阳性接受者中进行,即使CT值较低.
- 早期抗病毒治疗和密切监测对于在移植患者中管理COVID-19至关重要.
- 这一案例扩大了活跃SARS-CoV-2感染期间肺移植的有限文献.
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