向大脑-计算机接口多发性硬化症患者的运动康复
Marc Sebastián-Romagosa1, Woosang Cho2, Rupert Ortner1
1g.tec Medical Engineering Spain SL, Barcelona, Spain.
Frontiers in medicine
|January 21, 2026
概括
这项研究表明,一种带有功能电刺激的新型脑电脑接口可显著改善多发性硬化症症状,包括步态和移动性,长达六个月.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经退行性疾病,影响髓,导致疼痛,疲劳,认知问题和流动性丧失等症状.
- 目前的多发性硬化症治疗旨在减缓进展和控制症状,但治愈仍然难以捉摸.
- 一项初步研究探讨了一种针对多发性硬化症患者 (pwMS) 的新型干预措施,以解决步行障碍.
研究的目的:
- 评估运动图像大脑计算机接口 (MI-BCI) 与功能电刺激 (FES) 和虚拟现实相结合的有效性,以改善 pwMS 中的步态.
- 评估治疗效果的持续时间,直到干预后六个月.
主要方法:
- 一个单臂的初步研究招募了26个pwMS,其中24个完成了30个MI-BCI + FES会话.
- 包括行走耐力 (6分钟行走测试),运动/速度 (TUG,T25FW),性 (MAS) 和患者报告的结果 (MSIS-29,MFIS) 在基线,治疗后和随访 (长达37周) 评估的结果.
- 统计分析使用混合模型进行重复测量,以分析基线变化.
主要成果:
- 在行走耐力方面观察到显著的改善 (6MWT上增加37.3米,p < 0.001),超过了临床重要差异的最小值.
- 移动性和速度显著改善 (TUG和T25FW时间分别下降了-15.5%和-16.4%,p < 0.001).
- 性在MAS尺度上减少了大约1分,患者报告的结果显著改善 (MSIS-29:10.18分,MFIS:7.29分),效益持续了6个月.
结论:
- MI-BCI + FES系统在pwMS中显示了统计学显著和临床有意义的步态,移动性,性和患者报告的结果的改善.
- 这些积极影响在干预期结束后持续了长达六个月.
- 这些发现表明,这种新的干预措施是MS康复的有希望的,产生假设的方法.
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