第一次精神病发作中的自我干扰:理论框架和潜在的大麻相互作用 - - 一项系统性审查
Valerio Ricci1,2, Domenico De Berardis3, Giovanni Martinotti4
1San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.
Frontiers in psychiatry
|January 21, 2026
概括
大麻的使用,特别是高强度的THC,在早期精神病患者中显著增加了分离体验和自我干扰. 停止可能会扭转这些影响,强调需要综合评估和干预措施.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 环境健康 环境健康
背景情况:
- 大麻使用是精神疾病的危险因素.
- 新出现的证据将大麻素暴露,分离和自我干扰与早期精神病联系在一起.
研究的目的:
- 系统地审查异构,大麻使用和第一次精神病发作 (FEP) 中的自我干扰之间的现象学和神经生物学联系.
主要方法:
- 按照PRISMA指南进行系统审查.
- 从1990年到2025年搜索了四个数据库 (PubMed,Scopus,PsycINFO,Web of Science) 的数据.
- 包括22项研究,共3847名参与者.
主要成果:
- 在FEP患者中,大麻使用,特别是高强度THC,与明显增加的分离体验有关 (11-13分在DES-II).
- 每天使用高强度药物增加了临床显著解离 (OR:3.21) 和自我干扰的几率.
- 机制包括CB1受体的改变,内分泌大麻素系统的失调,以及神经网络的破坏.
结论:
- 与主要疾病相比,与大麻相关的分离有着独特的特征.
- 持续的症状预示着较差的功能结果和慢性.
- 大约75%的患者在戒大麻后表现出减少解离,这表明可逆性.
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