中国出生队列-环境和遗传因素 (CBC-EG) 研究:设计,目标,协议,发现和前景
Jiaqi Zhu1,2,3,4, Juan Chen1,2,3,4, Kai Zhao5
1Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Environment & health (Washington, D.C.)
|January 21, 2026
概括
中国出生队列-环境遗传因素 (CBC-EG) 研究调查了暴露组对母亲和胎儿健康的影响. 这项大规模的中国研究考察了影响怀孕结果和胚胎发育的环境和遗传因素.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 遗传学 是一个遗传学.
背景情况:
- 早期的人很容易受到环境暴露的影响,形成"暴露体".
- 以前的研究往往侧重于单一因素,忽视了环境对健康的综合影响.
- 考虑到环境-遗传相互作用,中国对母胎健康的大规模队列研究是有限的.
研究的目的:
- 建立对暴露基对中国孕产妇和胎儿健康的影响的全面了解.
- 分析环境暴露和行为因素对胚胎发育和怀孕疾病的影响.
- 探索环境-遗传相互作用,并确定怀孕不良结果的易受性位置.
主要方法:
- 建立了中国出生队列-环境遗传因素 (CBC-EG) 研究,这是一个跨越14个中国城市的多中心队列.
- 在2013年至2022年期间招募了101,437名孕妇.
- 使用外部暴露评估 (环境水平,行为) 和内部暴露评估 (生物标志物) 进行综合分析.
主要成果:
- 这项研究正在进行中,收集了有关环境暴露和遗传因素的大量数据.
- 预计初步发现将揭示暴露组与孕产妇/胎儿健康结果之间的关联.
- 研究将确定怀孕期间新出现的污染物及其特定威胁.
结论:
- CBC-EG研究提供了一个独特的,大规模的数据集,用于调查中国人口中的暴露组.
- 研究结果将提高对环境和遗传对孕产妇和胎儿健康的贡献的理解.
- 这项研究旨在为减轻怀孕期间环境风险的公共卫生战略提供信息.
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