发育性单二甲基酸盐暴露通过抑制CYP450转录通路损害后代的神经行为

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Jingcun Dong1,2, Jia Yin3, Shuang Liu1,4

  • 1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Environment & health (Washington, D.C.)
|January 21, 2026
PubMed
概括

在老鼠中,对单二乙基甲酸盐 (MEHP) 的发育暴露导致神经行为缺陷和海马体损伤. 这种酸盐破坏了细胞染色体P450通路,揭示了神经毒性的一种新机制.

关键词:
导致CYP450的失调.暴露 暴露 暴露单2-乙基基) 甲酸盐神经毒性 神经毒性在RNA-Seqq.

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