动脉样硬化中的分子机制和治疗进展:弥合免疫炎症和精准医学
Yimin Han1, Hongyi Xu1, Xinlei Yao1
1Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Key Laboratory of Neuroregeneration of Ministry of Education, Co-innovation Center of Neuroregeneration, Medical School of Nantong University, Nantong University, Nantong, Jiangsu, China.
Frontiers in immunology
|January 21, 2026
概括
本综述详细介绍了动脉样硬化病原体,重点关注由脂质驱动的炎症和免疫反应. 新兴疗法和精准医学方法被强调,以改善心血管疾病治疗.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
背景情况:
- 动脉样硬化是心血管疾病发病率和死亡率的主要原因.
- 它涉及脂质驱动的炎症和动脉重塑.
- 目前的治疗方法在解决复杂的病变发生方面存在局限性.
研究的目的:
- 系统地审查动脉样硬化病原学的最新进展.
- 总结不断发展的治疗策略.
- 探索用于精准医学的多奥米克和人工智能的整合.
主要方法:
- 文献综述侧重于内皮功能障碍,脂质障碍和免疫激活.
- 讨论细胞机制,如代谢重编程和编程细胞死亡.
- 对新型治疗途径和传统中医学的分析.
主要成果:
- 详细了解在动脉样硬化中代谢,免疫和血管细胞之间的相互作用.
- 识别新兴疗法,包括基于RNA的治疗方法和免疫调节疫苗.
- 通过多主题和人工智能集成,强调个性化医疗.
结论:
- 精准医学整合多种药物,单细胞技术和人工智能至关重要.
- 个性化风险预测和有针对性的干预措施是关键.
- 桥梁分子机制和临床管理将改善动脉样硬化治疗.
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