在一线免疫治疗的肝细胞癌患者中血清的预测值:一项回顾性研究
Xi Cheng1, Wei Wang1, Ya-Nan Xue1
1Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Frontiers in immunology
|January 21, 2026
概括
血清水平升高预测肝细胞癌 (HCC) 患者接受免疫治疗的结果更好. 较高的含量与改善的无进展生存率 (PFS) 和疾病控制率 (DCR) 相相关,这表明它是一种有价值的生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 血清会影响癌症中的免疫反应和抗瘤免疫力.
- 在接受一线免疫治疗的肝细胞癌 (HCC) 患者中,其对无进展生存率 (PFS) 和疾病控制率 (DCR) 的预测作用尚未得到研究.
研究的目的:
- 调查在接受一线免疫治疗的HCC患者的血清水平和临床结果 (PFS和DCR) 之间的相关性.
- 确定血清是否可以作为HCC免疫疗法反应的预测生物标志物.
主要方法:
- 在导出和验证队列中,对用免疫检查点抑制剂 (ICI) 治疗的HCC患者进行了回顾性分析.
- 接收器操作特征 (ROC) 曲线分析,以确定最佳的切线,以预测DCR.
- 卡普兰-梅尔分析以评估基于度的PFS.
主要成果:
- 一个基线血清水平≥0.785 mmol/L预测疾病控制 (AUC0.869).
- 水平较高的患者 (≥0.785 mmol/L) 的PFS中位数显著更长 (12.83个月与3.45个月在导出中;17.13个月与5.20个月在验证中) 和更高的DCR (96.25%与30%在导出中).
- 血清是PFS在单变量和多变量分析中的独立预测因素.
结论:
- 血清基线升高与在接受一线免疫治疗的HCC患者中改善PFS和DCR有关.
- 血清是一种潜在的具有成本效益和可访问的生物标志物,用于指导HCC的免疫疗法策略.
- 进一步的研究可能会探索补充来提高免疫疗法的疗效.
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