人类乳头瘤病毒疫苗接种与分娩率的关联
Tiina Koivisto1,2, Tiina Eriksson3, Mari Hokkanen3
1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Human vaccines & immunotherapeutics
|January 21, 2026
概括
人类乳头瘤病毒 (HPV) 疫苗接种没有显著影响整体分娩率. 然而,接受HPV疫苗接种并参加宫查的妇女的分娩稍有延迟,可能是由于咨询.
科学领域:
- 生殖健康 生殖健康
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 预防性人类乳头瘤病毒 (HPV) 疫苗对于预防宫癌至关重要.
- 关于HPV疫苗接种对生育能力和怀孕结果的影响的数据有限.
- 了解疫苗对分娩的影响对于公共卫生政策至关重要.
研究的目的:
- 调查HPV疫苗接种与分娩率之间的关联.
- 为了比较HPV疫苗接种,乙型肝炎病毒 (HBV) 疫苗接种和未接种妇女的分娩率.
- 在接种疫苗的群体中探索影响分娩时间的潜在因素.
主要方法:
- 基于注册表的研究设计.
- 包括接种过HPV疫苗 (n=6200),接种过HBV疫苗 (n=1667) 和未接种疫苗 (n=19,473) 的妇女.
- 比较每1万人/年的分娩数量和分娩率.
主要成果:
- 在接种疫苗和未接种疫苗的组中,第一次分娩的平均年龄相似 (22.9-23.4岁).
- 在28岁时,累计分娩比例为36.7% (接种HPV疫苗/接受查),46.9% (接种HBV疫苗) 和46.2% (未接种疫苗).
- 与未接种疫苗 (385/10,000人/年) 相比,接种HPV疫苗和查的妇女的分娩率较低 (306/10,000人/年).
结论:
- HPV 疫苗本身似乎不会对整体分娩率产生负面影响.
- 观察到 HPV 疫苗接种妇女参与并发宫查试验的潜在分娩延迟.
- 这种延迟可能归因于在查期间接受的性健康咨询,可能会推迟计划生育.
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