富含的超交联聚合物,用于在血液输液中快速和选择性去除胆红素
Hongxiang Yin1,2, Yueyuan Xiao1,2, Yucheng Cai1,2
1Key Laboratory of Green Preparation and Application for Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan, 430062, China. willieyan2003@hubu.edu.cn.
概括
一种新型的津醇功能化聚合物有效地去除胆红素,胆红素是一种在肝衰竭期间积累的毒素. 这种超交联聚合物 (HCP) 为肝脏疾病患者的血液输液治疗提供了有前途的进展.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 毒理学 毒理学 毒理学
背景情况:
- 肝衰竭导致有毒血液的积累,需要有效的去除恢复.
- 血 perfusion 是一种解毒方法,但吸附剂的性能是一个关键的限制.
研究的目的:
- 开发和评估一种新型的佐特醇功能化超交联聚合物 (HCP) 作为血液输液吸收剂.
- 评估吸附剂在去除肝衰竭中主要毒素 bilirubin 的有效性.
主要方法:
- 一种佐特醇功能化的超交联聚合物 (HCP) 的合成.
- 评估医疗保健工作人员作为血液输液吸收剂的性能,以去除胆红素.
- 胆红素吸附能力的量化 (最大和平衡).
主要成果:
- 合成的HCP在胆红素捕获方面表现出色.
- 最大吸附能力达到了877毫克-1克.
- 均衡吸附能力为195毫克-1克.
结论:
- 佐特醇功能化的HCP显示出作为血液输液吸收剂的显著潜力.
- 这项研究扩大了医疗保健人员在生物医学解毒中的应用.
- 提出了开发先进的输血吸收剂的可行策略.
更多相关视频
相关概念视频
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
200
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
200
Polymers
40.5K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
40.5K
The Nitrogen Cycle
59.6K
Nitrogen atoms, present in all proteins and DNA, are recycled between abiotic and biotic components of the ecosystem. However, the primary form of nitrogen on Earth is nitrogen gas, which cannot be used by most animals and plants. Thus, nitrogen gas must first be converted into a usable form by nitrogen-fixing bacteria before it can be cycled through other living organisms. The use of nitrogen-containing fertilizers and animal waste products in human agriculture has greatly influenced the...
59.6K
Crossing Over
169.4K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
169.4K
Covalently Linked Protein Regulators
8.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
8.7K
Overview of Nitrogen Metabolism
11.0K
Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of ammonia, ammonium ions, nitrate, nitrite, or nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
11.0K


