在与肥胖相关的膝关节关节炎中改变了肠道微生物群和宿主通路
Jingyi Huang1, Ming Liu1, Hongwei Zhang2
1Human Genetics & Genomics, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Clinical and experimental rheumatology
|January 21, 2026
概括
肥胖和膝关节骨关节炎患者表现出与代谢和蛋白质改变相关的肠道微生物变化. 这些肠道微生物组的变化可能会使骨关节炎恶化,并提出新的治疗目标.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 蛋白质组学是指蛋白质组学.
- 骨关节炎的研究研究.
背景情况:
- 肥胖 (OB) 显著影响膝关节骨关节炎 (OA) 的发病.
- 肠道微生物失调症与各种慢性疾病有关.
- 肠道微生物群,新陈代谢和OA之间的相互作用尚未完全理解.
研究的目的:
- 为了研究与肥胖相关的膝关节骨关节炎的肠道微生物变化.
- 通过使用多omics数据,探索这些微生物变化的功能后果.
- 整合微生物组,代谢组,蛋白质组和饮食数据进行全面分析.
主要方法:
- 从91名膝关节OA患者和12名对照人群收集了便和血样本,按OB和OA状态分类.
- 进行了16S rRNA基因测序,用于肠道微生物群的概况.
- 综合性血代谢组学 (630种代谢物) 和蛋白质组学 (5,416种蛋白质) 与微生物数据,使用MaAsLin2建模和饮食摄入量调整.
主要成果:
- 与OB-OA+患者相比,肥胖+OA+患者的肠道微生物多样性减少.
- 17种微生物种类与OB+OA+有显著的关联,在调整后剩下的16种.
- 这些种类与改变的代谢物通路 (例如脂肪酸生物合成) 和蛋白质通路 (例如PI3K-Akt信号传递,脂质代谢) 相关联.
结论:
- 与肥胖相关的膝关节骨关节炎的特征是肠道微生物失调症.
- 这种失生症与与OA相关的全身代谢和蛋白质基因变化有关.
- 微生物组-代谢组-蛋白质组轴为肥胖个体和潜在的治疗点中OA进展提供了机械洞察力.
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