在心力衰竭患者中评估可溶性ST2和加列-3水平
Mustafa Çetin1, Zulkif Tanrıverdi2, Recep Demirbağ2
1Clinic of Cardiology, Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Türkiye.
概括
溶性ST2 (sST2) 和加勒-3在心力衰竭中升高,心力衰竭的喷射分数 (EF) 降低或轻微降低,这表明它们在HF分类中的作用. 与对照组相比,这些生物标志物与保存EF患者的心脏衰竭没有差异.
科学领域:
- 心脏病学 心脏病学
- 生物标志物研究 生物标志物研究
- 心脏衰竭病理生理学 病理生理学
背景情况:
- 可溶性ST2 (sST2) 和加勒-3是心力衰竭 (HF) 的已确定的预后标志物.
- 它们在基于射出分数 (EF) 的HF分类中的作用仍未得到充分研究.
研究的目的:
- 评估sST2和galectin-3在基于EF的HF患者分类中的诊断实用性.
- 为了在不同HF亚型和健康对照中比较sST2和galectin-3水平.
主要方法:
- 横截面研究包括41名患者,每个患者的HFrEF (EF ≤40%),HFmrEF (EF 41-49%),HFpEF (EF ≥50%),和41名健康对照.
- 测量血清中的sST2和galectin-3水平.
- 各组生物标志物水平的统计比较以及与EF和BNP的相关性分析.
主要成果:
- 在研究组中观察到sST2和galectin-3水平的显著差异 (分别P < 0.001和P = 0.007).
- 与对照组相比,患有HFrEF和HFmrEF的患者表现出明显更高的sST2和加勒-3水平 (P ≤ 0.001).
- 在HFpEF患者和对照人群 (P > 0.4) 之间,没有发现sST2和galectin-3水平的显著差异.
- sST2和加勒-3水平与BNP正相关,与EF负相关 (P <0.028).
结论:
- 在HFrEF和HFmrEF中,sST2和加勒-3水平升高,与EF降低相关.
- 这些生物标志物不能区分HFpEF和健康个体.
- sST2 和 galectin-3 显示出具有降低射出分数的 HF 亚型的潜在歧视者.
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