在数字增强的生活方式干预中添加胺-托皮拉酸:双盲随机临床试验
Alejandro Campos1, Wissam Ghusn1, Lizeth Cifuentes1
1Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Obesity (Silver Spring, Md.)
|January 21, 2026
概括
芬太胺-托皮拉-ER与数字生活方式干预相结合,在12个月内显著降低了肥胖成人体重和心血管疾病风险.
科学领域:
- 肥胖医学 肥胖医学
- 预防心血管疾病 预防心血管疾病
- 数字健康干预措施 数字健康干预措施
背景情况:
- 肥胖是心血管疾病 (CVD) 的一个主要风险因素.
- 有效的体重管理策略对于降低心血管疾病风险至关重要.
- 数字增强的生活方式干预 (DELI) 在肥胖管理方面表现有前途.
研究的目的:
- 为了比较芬特明-托皮拉-ER加DELI与安慰剂加DELI的疗效.
- 评估对减肥和心血管疾病风险标志物的影响.
- 为了评估12个月的持续影响.
主要方法:
- 一个为期12个月的随机,双盲,安慰剂对照试验.
- 八十名患有肥胖症 (BMI ≥30 kg/m2) 的参与者被录取.
- 干预包括与面对面/远程医疗,应用程序和连接设备的DELI,以及芬特明-托皮拉-ER或安慰剂.
主要成果:
- 芬太胺-托皮拉-ER组在3个月 (10.82公斤 vs 4.04公斤) 和12个月 (15.32公斤 vs 5.85公斤) 实现了显著更大的体重减轻.
- 与基线相比,药物组显示动脉样硬化心血管疾病风险估计显著降低 (3.35%).
- 3个月和12个月体重减轻差异的p值分别为p=0.002和p<0.001. 心血管疾病风险降低 p=0.004.4.
结论:
- 作为DELI的辅助剂,芬特明-托皮拉-ER导致肥胖成年人显著和持续的体重减轻.
- 这种组合治疗有效降低了心血管疾病的风险.
- 这些发现支持使用药物治疗与数字健康干预措施一起用于肥胖管理.
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