肝细胞癌患者的治疗延迟和生存率:一个多中心队列研究
Mohammad Jarrah1, Nicole E Rich1,2, Gloria Figueroa3
1Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX.
The American journal of gastroenterology
|January 21, 2026
概括
超过五分之一的肝细胞癌 (HCC) 患者经历了超过90天的治疗延迟. 然而,在这个多中心队列研究中,这些延迟并没有显著影响整体存活率.
科学领域:
- 肝病学和瘤学 肝病学和瘤学
- 癌症治疗研究 癌症治疗研究
- 医疗保健服务研究 医疗服务研究
背景情况:
- 治疗延迟是癌症护理的一个问题,但关于其患病率,原因和肝细胞癌 (HCC) 存活影响的数据有限.
- 这项研究通过在多中心的HCC患者队列中检查这些因素来弥补这一差距.
研究的目的:
- 为了确定HCC患者治疗延迟的患病率.
- 确定与这些延迟相关的因素.
- 评估治疗延迟对整体存活时间的影响.
主要方法:
- 一项回顾性队列研究对1561名在2010年至2018年期间在四个美国卫生系统中被诊断出HCC患者进行.
- 治疗延迟被定义为在诊断后90天以上开始治疗.
- 使用后勤和考克斯回归模型来分析与延迟相关的因素及其对生存的影响.
主要成果:
- 治疗延迟 (>90天) 在22.9%的HCC患者中发生.
- 患有BCLC阶段0 HCC的患者更有可能出现延迟,而男性和患有BCLC阶段C HCC的患者则不太可能.
- 六个月的基准分析显示,延迟治疗和及时治疗的患者在整体存活率上没有显著差异.
结论:
- 超过五分之一的HCC患者经历了显著的治疗延迟.
- 尽管延迟的普遍性,但这项研究发现没有统计学上显著的关联与减少的整体存活时间.
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