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在胃肠道和肝脏疾病中成
Sasha Deutsch-Link1, Isabelle S Byers1, Hyundam Gu2
1Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.
The American journal of gastroenterology
|January 21, 2026
概括
本综述涵盖了酒精,阿片类药物和大麻使用障碍及其对胃肠道和肝脏疾病的影响. 早期识别和多学科护理改善了成和肝脏疾病的结果.
科学领域:
- 胃肠病学和肝病学
- 成 药物 药物 药物 药物
- 内部医学 内部医学
背景情况:
- 药物使用障碍显著影响胃肠道 (GI) 和肝脏疾病的发展和进展.
- 酒精相关性肝病 (ALD) 是导致美国肝病和肝移植的主要原因.
- 阿片类药物和大麻使用障碍存在独特的胃肠道和肝脏并发症.
研究的目的:
- 在胃肠病学和肝病学中审查临床相关的物质使用障碍.
- 突出酒精,阿片类药物和大麻使用障碍对胃肠道和肝脏健康的影响.
- 强调在管理这些疾病时需要综合护理.
主要方法:
- 在胃肠病学和肝病学中对物质使用障碍的文献综述.
- 对酒精使用障碍 (AUD) 对肝病和肠道恶性瘤的影响分析.
- 检查阿片类药物和大麻使用障碍对胃肠道运动,肝毒性和感染风险的影响.
主要成果:
- AUD与与酒精相关的肝病和胃肠道癌症有关;这是肝移植的主要征兆.
- 阿片类药物使用障碍与运动性问题,便秘和增加C型肝炎风险有关.
- 大麻使用障碍会导致高血压综合征,而合成大麻素是肝毒性的.
结论:
- 有效的管理需要一个多学科的方法,结合行为干预和药物治疗.
- 治疗AUD和阿片类药物使用障碍的药物未得到充分利用,尽管已证明其安全性和有效性,即使在肝功能障碍中也是如此.
- 胃肠病学家和肝病学家在早期识别和协调护理中发挥着至关重要的作用,以改善成和胃肠道/肝脏结果.
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