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Updated: Jan 22, 2026

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
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Ω-Loop 突变通过调节 PDC-3 β-乳酸酶中的键网络来控制活性位点的动态

Shuang Chen1, Andrew R Mack2,3, Andrea M Hujer2,4

  • 1University College London, London, United Kingdom.

eLife
|January 21, 2026
PubMed
概括

Pseudomonas-derived cephalosporinase-3 (PDC-3) 的 Ω-循环中的突变增强了其抗生素失活的功能. 这些变化改变了酶的结构和动力学,有助于Pseudomonas aeruginosa对胞的抵抗.

关键词:
伪omonas aeruginosa 这种类型的病毒.适应性的强盗分子生物物理学分子生物物理学分子动力学分子动力学没有,没有,没有.结构生物学结构生物学这就是β-乳酸酶.

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