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需要在常规物质查小组中包括普雷加巴林,以检测非治疗性使用和滥用
Saliha Aksun1,2, Başak Bağci3, Oğuz Karalar1,2
1Department of Medical Biochemistry, İzmir Katip Çelebi University Medical Faculty, İzmir, Türkiye.
Psychiatry and clinical psychopharmacology
|January 21, 2026
概括
在土耳其,滥用普雷加巴林是未被认可的,每年有15-18%的尿样呈阳性检测. 扩大药物查小组,包括普雷加巴林,对于解决这种诊断缺口和改善物质使用障碍治疗至关重要.
科学领域:
- 临床生物化学 临床生物化学
- 法医毒理学 法医毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 用于神经和精神疾病的Pregabalin显示出越来越多的滥用潜力.
- 在土耳其的标准尿液药物查排除了普雷加巴林,尽管它具有精神活性作用和滥用.
- 这种差距导致人们对普雷加巴林滥用的认识不足.
研究的目的:
- 通过生物化学实验室数据评估pregabalin滥用的流行率.
- 突出在常规毒理学查中包括普雷加巴林的必要性.
- 在毒理学报告中引入"不完全负面"概念.
主要方法:
- 对2019-2024年尿液药物查结果的回顾性分析.
- 对140多种物质进行验证的液体染色学-双重质谱法,包括普雷加巴林和 gabapentin.
- 在单次使用和多重药物组之间,普雷加巴林度的统计比较.
主要成果:
- 普雷加巴林每年在15-18%的尿样中检测到,有时超过甲基胺检测.
- 积极的病例经常与缓刑服务和成治疗中心有关.
- 与同样检测到的物质 (大麻,甲基胺) 观察到更高的普雷加巴林度,但显著的亚组仅使用了普雷加巴林,导致虚假阴性.
结论:
- 由于查的局限性,对普雷加巴林的滥用未被充分认识到.
- 在常规药物小组中包括普雷加巴林是可行的,而且迫切需要.
- "不完全负面"的概念强调需要修订国家毒理学实践和扩大查小组.
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