避免使用治疗所需的复合数来计算每事件的成本
Joshua Toliver1, Julia Wang1, Jigish Bhavsar1
1Novo Nordisk Inc, Plainsboro, New Jersey, USA.
使用复合终点来计算需要治疗的数量 (NNT) 和每次事件避免的成本 (CPEA) 揭示了塞马格卢提德和杜拉格卢提德对心血管疾病的全部临床和经济价值.
科学领域:
- 心血管医学 心血管医学
- 卫生经济学 卫生经济学
- 药物经济学 药物经济学
背景情况:
- 需要治疗的数量 (NNT) 和每次事件的成本 (CPEA) 是评估慢性治疗价值的标准指标,通常基于初级试验终点.
- 这种传统方法可能会低估治疗的完整临床和经济效益,因为它排除了超出主要终点的结果.
研究的目的:
- 开发复合NNT并导出CPEA以估计在已确定的心血管疾病患者中塞马格卢和杜拉格卢的综合价值.
- 突出主要终点为重点的NNT/CPEA计算的局限性,并倡导更广泛的结果措施.
主要方法:
- 利用了来自两个心血管结局试验的数据:SELECT (西马格卢提德) 和REWIND (杜拉格卢提德).
- 使用复合终点计算NNT和CPEA,包括3点主要不良心血管事件 (MACE-3),5点MACE (MACE-5) 和心血管--代谢 (CKM) 事件.
主要成果:
- 随着更广泛的复合终点,NNT降低了:NNTCKM为塞马格卢提德的8个,对杜拉格卢提德的23个,相比之下,NNTMACE-3分别为67和72.
- 综合终点的CPEA也下降了:CKM事件的CPEA为塞马格卢提德的190,387美元和杜拉格卢提德的607,886美元,明显低于MACE-3.
结论:
- 仅基于初级终点的NNT和CPEA计算无法捕捉像西马格卢提德和杜拉格卢提德这样的治疗方法的总值.
- 使用涵盖更广泛益处的复合终点,可以更准确地评估治疗价值和成本效益.
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