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波尔特佐米布诱导的感觉神经听力损失可能是可逆的与内德克萨米他
Natalia Peláez Casillas1, Jose Maria Verdaguer Muñoz2, Antonio Rodríguez Valiente1
1Servicio de Otorrinolaringología, Hospital Universitario Puerta de Hierro Majadahonda, Deparmento de Cirugía, Facultad de Medicina, Universidad Autónoma de Madrid, IDIPHISA, 28222 Majadahonda, Madrid, Spain.
用于多发性骨髓瘤的博特佐米布很少会导致听力损失 (听力毒性). 早期使用内膜内甲治疗可能有助于恢复听力,并允许继续化疗.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 博尔特佐米布是一种蛋白酶体抑制剂,通常用于多发性骨髓瘤 (MM).
- 虽然周围神经病变是一种已知的副作用,但博尔特佐米布诱导的耳毒性很少见,并且未得到充分承认.
- 本报告详细介绍了一例与博雷佐米布治疗相关的突然听力损失病例.
研究的目的:
- 报告一种罕见的博尔特佐米布诱导的耳毒性病例.
- 为了强调这种不良事件的潜在可逆性.
- 为了评估肠内皮质类固醇治疗的疗效.
主要方法:
- 一个74岁的MM患者的病例研究.
- 诊断听力学和内部听力通道的MRI.
- 治疗方法是注射入门内德克萨米他.
- 监测听力对博雷佐米布再暴露和治疗的反应.
主要成果:
- 患者经历了伯特佐米布的管理后突然的单边感应神经神经听力损失.
- 听力测量证实了严重的听力损失;MRI是正常的.
- 内甲导致部分听力恢复.
- 听力损失在再次暴露于博尔特佐米布后复发,但在治疗后再次改善.
结论:
- 与博特佐米布相关的耳毒性是多发性骨髓瘤治疗的罕见但潜在可逆并发症.
- 内皮质类固醇治疗可能是减轻耳损伤的可行选择.
- 这种方法可以允许在响应的患者中继续有效的博特佐米布化疗.
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