在新生儿发作中使用Levétiracetam的有效性:一项回顾性队列研究
Faisal Aqeel Alsehli1,2,3, Jahad Alghamdi4, Abdulaziz Homedi1,2,3
1Neonatal Intensive Care, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh 11481, Saudi Arabia.
NeuroSci
|January 21, 2026
概括
与芬巴比他 (PB) 相比,Levétiracetam (LEV) 在新生儿发作中显示出更高的安全性,副作用较少. 虽然PB提供了急性发作抑制,但LEV是一种安全有效的补充疗法,用于新生儿发作管理.
科学领域:
- 新生儿神经病学 新生儿神经病学
- 儿科药理学 儿科药理学
- 临床研究研究 临床
背景情况:
- 新生儿发作在新生儿重症监护室 (NICU) 很常见,特别是在早产婴儿中.
- 费诺巴比他 (PB) 是一种标准治疗方法,但对于新生儿发作,关于 levetiracetam (LEV) 的数据有限.
研究的目的:
- 评估 levetiracetam 在新生儿中实现无发作的疗效.
- 在新生儿群体中调查 levetiracetam 的安全性.
- 为了比较 levetiracetam 与新生儿发作管理中的 phenobarbital.
主要方法:
- 在2016年12月至2020年1月期间入院于NICU的48名新生儿的回顾性队列研究.
- 患者被分为两组:28组接受了费诺巴比塔尔,20组接受了 levetiracetam.
- 分析了医疗记录,以控制发作和不良事件.
主要成果:
- 费诺巴比塔尔在22/28新生儿中实现了无发作,而 levetiracetam在11/20 (通常在PB失败后) 实现了控制.
- 芬诺巴比他与57%的新生儿的副作用有关,而 levetiracetam 只有10%的副作用.
- 列维他证明了优越的安全性,没有严重的不良事件,并控制了83%的发作作为附加治疗.
结论:
- 莱维特拉是一种安全有效的替代品或辅助新生儿发作的phenobarbital.
- 莱维可以减轻与GABAergic药物如巴比塔尔相关的神经毒性风险.
- 持续的EEG监测对于确保停止和避免电临床分离至关重要.
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