液体三醇i-Octyl POSS在实验性肺损伤中实现了快速血液静止和肺静止
Michelle Tucci1, Robert C O Brien2, Joseph D Lichtenhan3
1Anesthesiology, University of Mississippi Medical Center (UMMC), Jackson, MS 39216, USA.
概括
新的粘液化合物,POSS和PC,在医院前创伤模型中有效地阻止肺部出血和空气泄漏. 这些治疗方法提供快速的血液静止和无压缩的肺静止,对严重的肺损伤有希望.
科学领域:
- 生物材料科学 生物材料科学
- 创伤外科 手术 创伤外科
- 紧急医疗 紧急医疗
背景情况:
- 对于非压缩性肺损伤,没有有效的医院前干预措施.
- 粘性液体化合物,如多面性寡合性丝素 (POSS),显示出对控制出血的潜力.
- 可以通过高 (PK) 或 (PC) 增强POSS疗效.
研究的目的:
- 评估POSS,PK和PC在猪模型中治疗切口肺伤的疗效.
- 评估这些新型化合物的血液静止和肺静止能力.
- 确定它们在创伤护理中用于医院前应用的潜力.
主要方法:
- 在猪 (n=10) 中通过胸腔切除术创建了切口肺部伤口.
- 治疗包括没有治疗 (UNT),加压 (GC),POSS,PK或PC (1.5毫升).
- 观察伤口10分钟,以评估血液静止和肺静止.
主要成果:
- 在8/10个伤口中,POSS和PC实现了静血,比GC (8分钟) 快得多.
- POSS (2分钟) 和PC (1.4分钟) 显示出快速的凝血.
- 通过POSS,PC和PK实现了完整的肺静止,与GC不同.
结论:
- 液体POSS化合物,特别是POSS和PC,提供快速和持续的出血和气动控制.
- 这些药物不需要压缩,因此适合用于医院前的环境.
- 结果支持使用这些POSS化合物治疗非压缩性肺创伤.
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