在"Seguimiento Universidad de Navarra" (SUN) 队列中,地中海饮酒模式和与酒精有关的癌症发生率
María Barbería-Latasa1,2, Estefanía Toledo1,2,3, Maira Bes-Rastrollo1,2,3
1Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain.
Medical sciences (Basel, Switzerland)
|January 21, 2026
概括
地中海饮酒模式 (MADP) 可能会降低男性的癌症风险,但不是女性. 坚持MADP,包括饮食时适度饮用,避免暴饮暴酒,显示男性与酒精有关的癌症发病率显著降低.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 酒精消费是已知的致癌物,与七种主要癌症类型有关.
- 现有的指导方针强调总体饮酒量,但饮酒模式可能会影响癌症风险.
- 地中海饮酒模式 (MADP) 与降低死亡率和疾病有关,但其癌症特异性影响尚未研究.
研究的目的:
- 调查遵守地中海饮酒模式 (MADP) 与七种与酒精有关的癌症发生率之间的联系.
- 确定饮酒模式是否会改变酒精与癌症风险之间的已确定的联系.
- 通过考虑饮酒模式以及消费水平,为癌症预防策略提供信息.
主要方法:
- 这是一项针对SUN (Seguimiento Universidad de Navarra) 队列中的19,541名参与者的前性队列研究.
- 参与者被跟踪了平均13.8年.
- 个人根据MADP的坚持被分类为:禁酒者,低,中等和高坚持群体.
主要成果:
- 对MADP的高度坚持与男性与酒精有关的癌症发病率大幅降低有关 (HR=0.44,95% CI [0.21-0.92]).
- 对MADP的适度坚持表明男性癌症风险降低的趋势 (HR=0.56,95% CI [0.30-1.06]).
- 在女性中,没有观察到MADP坚持和与酒精有关的癌症发病率之间的统计学意义上的关联.
结论:
- 关于酒精消费和癌症风险的性别具体建议是合理的.
- 在男性中,地中海饮酒模式 (MADP) 可能会保护男性免受与酒精有关的癌症,而这与饮酒量无关.
- 根据这项研究的发现,MADP没有证明对女性的与酒精有关的癌症有显著的益处.
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