进行治疗意图切除的肝内胆管癌患者的术前预后得分
Jarin Chindaprasirt1,2, Thanachai Sanlung1,2, Piyakarn Watcharenwong1,2
1Medical Oncology Program, Department of Medicine Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand.
Medical sciences (Basel, Switzerland)
|January 21, 2026
概括
手术前的中性粒细胞与淋巴细胞比率 (NLR) 预测切除后肝脏内胆固醇癌 (iCCA) 患者的结果会更差. 这个标记是这个标记.
科学领域:
- 在瘤学瘤学.
- 肝胆道手术 肝胆道手术
- 癌症生物标志物 癌症生物标志物
背景情况:
- 手术前的炎症和营养标志物如NLR,LMR,PNI和CONUT在癌症中具有预后价值.
- 它们在治疗切除后的肝脏内胆固醇癌 (iCCA) 亚组中的比较预测效用尚未确定.
研究的目的:
- 为了评估术前中性粒细胞与淋巴细胞比率 (NLR),淋巴细胞与单细胞比率 (LMR),预后营养指数 (PNI) 和控制营养状况 (CONUT) 评分的预后意义.
- 评估它们在治疗意图切除的肝内胆管癌 (iCCA) 患者中复发和生存的预测价值.
主要方法:
- 对213名接受治疗切除的iCCA患者 (2015-2021) 的回顾性分析.
- 从实验室数据计算手术前的NLR,LMR,PNI和CONUT得分.
- 使用考克斯回归和卡普兰-梅尔方法分析临床病理变量,复发和生存率.
主要成果:
- 术前NLR升高 (≥2.4) 独立预测较差的无病存活率 (DFS) 和整体存活率 (OS).
- 这种关联在R0切除的患者和出现复发的患者中持续存在.
- 在R0切除和复发子组中,CONUT评分与OS相关;瘤形态是一个重要的术后因素.
结论:
- 手术前的NLR是iCCA患者进行治疗切除时DFS和OS恶化的重要预测因素.
- 在R0切除和复发子组中,NLR的预后影响是一致的.
- CONUT评分具有有限的独立预测价值,主要是在R0切除的复发病例中.
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