社会经济决定因素是否影响DPYD测试? 一项对1478名癌症患者进行的现实研究,这些癌症患者接受了胺化学疗法
Bahaaeldin Baraka1, Navin Mathiyalagan1, Maryam Al-Ani1
1Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
Medical sciences (Basel, Switzerland)
|January 21, 2026
概括
影响化疗药物代谢的DPYD基因变异影响了7%的癌症患者. 在这项研究中,测试可访问性与社会经济地位无关.
科学领域:
- 药物基因组学 药物基因组学
- 在瘤学瘤学.
- 临床遗传学 临床遗传学
背景情况:
- DPYD基因提供了制造二皮里米丁脱酶 (DPD) 的指令.
- DPD对于代谢关键化疗药物,如capecitabine和5-fluorouracil (5-FU) 是至关重要的.
- DPYD变种可能会导致这些必要的癌症治疗方法的严重毒性.
研究的目的:
- 为了确定DPYD变体在多样化癌症患者队列中的流行率.
- 调查DPYD变异与瘤类型和患者人口统计学的关联.
- 评估社会经济因素对DPYD测试率的影响.
主要方法:
- 分析了在诺丁汉大学医院治疗的1478名癌症患者的数据 (2021年12月至2023年12月).
- 在各种瘤类型和种族群体中评估DPYD变异频率.
- 与社会经济地位相关的DPYD测试率的评估.
主要成果:
- 在总患者队列的7%中检测到DPYD变异.
- 在结直肠癌患者 (7.9%) 和高加索人群 (7.4%) 中观察到更高的患病率.
- c.1129-5923C>G (HapB3) 变种是最常见的,在75.7%的变种阳性病例中存在.
结论:
- 在癌症患者中,DPYD变异很常见,影响药物代谢和毒性.
- 由于DPYD变异的流行,需要对个性化化疗进行药物遗传查.
- 社会经济地位没有影响该研究队列的DPYD测试率.
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