药物操纵在儿科护理中:对一个广泛的实践进行范围审查,表明制药供应中的系统性缺口
Charlotte Vermehren1,2,3, Laura Giraldi1, Sarah Al-Rubai1
1Department of Clinical Pharmacology, Copenhagen University Hospital-Bispebjerg and Frederiksberg, 2400 Copenhagen, Denmark.
Pharmacy (Basel, Switzerland)
|January 21, 2026
概括
在儿童中,涉及改变成人药物的药物操纵是常见的,因为缺乏儿科配方. 这种实践突出了药物开发,监管和儿童药物疗法获取的系统性问题.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 儿科医学 儿科医学
- 卫生政策和法规 卫生政策和法规
背景情况:
- 儿科患者经常接受由成人配方修改的药物,这表明适合年龄的药物产品缺乏.
- 这些常规操纵可能意味着儿科药物治疗中的潜在系统性问题.
研究的目的:
- 进行范围审查,绘制儿科药物操纵的流行率,定义和类型.
- 分析药物操纵作为表述科学,监管框架和药物获取的结构性缺陷的指标.
主要方法:
- 在PubMed上进行了系统的文献搜索,涵盖了2014年1月至2024年7月期间发表的研究.
- 纳入了10项报告儿科患者 (≤18岁) 药物操纵频率的研究,并根据PRISMA-ScR指南进行了叙事综合.
主要成果:
- 包括来自9个国家的研究报告了药物操纵频率从6.4%到62%的管理和高达60%的患者水平.
- 通过分散,分裂或粉碎改变的口服固体剂型是最常见的操作. 在不同研究中,定义和方法有很大差异.
- 确定了五个关键的结构性缺陷:有限的儿科配方,不一致的监管实践,缺乏标准化定义,安全数据不足和区域访问差异.
结论:
- 针对儿科使用的药物配方的广泛操纵是一个可衡量的问题,反映了药物配方,监管和获取方面的系统性不足.
- 将药物操纵视为结构性指标可以为政策提供信息,推动创新,并在全球范围内促进公平的儿科药物治疗.
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