在慢性脊髓损伤中治疗胃肠道不适的益生菌和益生菌补充剂 (PRO-GIDSCI):一个随机控制的交叉试验协议
Julia Trunz1,2, Cyra Schmandt1,3, Anneke Hertig-Godeschalk1
1Swiss Paraplegic Research, 6207 Nottwil, Switzerland.
Methods and protocols
|January 21, 2026
概括
这项研究调查了益生菌和益生菌对脊髓损伤 (SCI) 患者胃肠道症状的影响. 这些发现旨在改善肠道健康和生活质量.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 胃肠道 (GI) 的不适影响到70%的脊髓损伤 (SCI) 患者.
- 肠道功能失调,改变过渡时间和减少肠道动性有助于SCI中的这些症状.
- 关于益生菌和益生菌在SCI中治疗胃肠道问题的疗效的数据有限.
研究的目的:
- 评估益生菌和益生菌补充剂对慢性SCI患者的胃肠道症状和生活质量的影响.
- 评估胃肠道过渡时间的变化,炎症标志物和肠道微生物组合.
主要方法:
- 一个单一中心随机对照交叉试验,涉及慢性SCI (≥1年) 和显著的GI症状的成年人 (≥18岁).
- 参与者被随机分配,接受益生菌或益生菌补充剂八周,然后是四周的洗期,然后是替代补充剂.
- 排除标准包括目前的抗生素使用,相关的饮食/消化障碍或最近的饮食变化.
主要成果:
- 主要的结果指标是胃肠道生活质量指数.
- 二次结果包括胃肠道过渡时间,炎症性血液标志物和肠道微生物组合.
- 数据分析将确定益生菌和益生菌干预措施的比较效果.
结论:
- 这项试验将提供关于益生菌和益生菌在SCI中治疗胃肠道功能障碍的有效性的关键数据.
- 这些发现可能会为临床实践提供信息,并改善SCI相关的肠道疾病患者的患者结果.
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