高频左侧重复性跨脑磁性刺激 (rTMS) 治疗创伤后应激障碍与并发性严重抑郁症
Natalie Seiler1,2, Thomas P Nguyen2,3,4, Amy Coelen2
1Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia.
International journal of psychiatry in medicine
|January 21, 2026
概括
高频率的左侧重复性横磁刺激 (rTMS) 有效地减少了患有严重抑郁症 (MDD) 和创伤后应激障碍 (PTSD) 的患者的症状. 这种治疗耐受性很好,症状明显改善,住院时间缩短.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床医学 临床医学
背景情况:
- 重复性横磁刺激 (rTMS) 是一种公认的治疗方法,用于同时发生的创伤后应激障碍 (PTSD) 和严重抑郁障碍 (MDD).
- 目前的rTMS协议缺乏标准化,特别是对于军事人员和患有PTSD和MDD并发症的急救人员.
研究的目的:
- 描述高频rTMS对伴随性PTSD和MDD的住院患者的左背侧前额叶皮层 (DLPFC) 应用的结果.
- 为了评估这个特定的rTMS协议的有效性和耐受性.
主要方法:
- 对于在2017年1月1日至2024年12月1日期间接受≥10次rTMS治疗的成人住院患者的患者档案的回顾性审查.
- 配对的t测试被用来分析症状得分的变化 (MADRS,PCL-5,HoNOS,MoCA).
主要成果:
- 高频率的左侧DLPFCrTMS被给予了89.8%的患者 (n=106).
- 左侧的rTMS与显著改善的MADRS,PCL-5,HoNOS和MoCA分数相关.
- 接受左侧rTMS的患者治疗次数较少,入院时间较短,尽管近一半的患者需要再入院.
结论:
- 高频左侧rTMS通常可以很好地耐受并发性PTSD和MDD.
- 这种治疗显示出降低抑郁症和PTSD症状的潜力.
- 需要对rTMS亚型进行进一步的研究,以规范护理并制定最佳治疗指南.
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