循环胺诱导的出血性心肌炎
Rade R Jibawi Rivera1, David M Harmon2, Joerg Herrmann2
1Deparment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
JACC. Case reports
|January 21, 2026
概括
环胺可以引起罕见的出血性心肌炎,即使在剂量低于100毫克/公斤. 早期的心脏成像对于诊断这种非致命的心脏毒性至关重要.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 环胺是一种常见的化疗药物.
- 它可以引起各种毒性,包括罕见的出血性心肌炎.
- 这一案例是这种毒性的非致命实例.
研究的目的:
- 报告一个非致命的循环胺诱导出血性心肌炎病例.
- 为了强调早期诊断这种罕见的毒性的重要性.
- 为了强调多式心脏成像的实用性.
主要方法:
- 一名63岁的患有骨髓纤维化症的男性接受了95mg/kg环胺调节剂以进行干细胞移植.
- 患者出现了暗示心力衰竭的症状,心脏生物标志物升高.
- 诊断工作包括心电图,心声图和心脏磁共振成像.
主要成果:
- 患者出现了心动减速,胀和肺部拥堵.
- 心脏成像显示了心肌胀,炎症和心脏内出血.
- 生物标志物显示Troponin-T和N-终端前脑尿素的显著升高.
结论:
- 这是首个报告的非致命的循环胺诱导出血性心肌炎的病例,剂量低于100毫克/公斤.
- 对于疑似循环胺心脏毒性病例,迅速的多式心脏成像是必不可少的.
- 早期诊断和管理可以带来有利的结果.
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