心脏骤停从硫氧化对比 过敏反应 经过先前的甲过敏后的过敏反应
Douglas R Corsi1, Christian Simon1, Naresh Nagella1
1Division of Cardiovascular Disease, Department of Internal Medicine, Rutgers University, New Brunswick, New Jersey, USA.
对超声波增强剂 (UEA) 的严重过敏反应很少见,但有可能发生. 这一案例突出显示,一个患有先前过敏对相关药物过敏的患者对硫六化物脂质微球的危及生命的过敏反应.
科学领域:
- 放射学 放射学是一门学科.
- 过敏和免疫学 过敏和免疫学
- 心脏病学 心脏病学
背景情况:
- 超声波增强剂 (UEA) 被广泛使用,并且通常是安全的.
- 对UEA的严重不良反应并不常见,不同药物之间的交叉反应性尚未得到充分证实.
- 现有的指导方针允许在患有先前过敏对素脂微球 (PLM) 的患者中使用硫六化物脂微球 (SFM).
研究的目的:
- 报告一种罕见的过敏反应和心脏骤停病例,该病例发生在曾经对PLM过敏的患者中,后者接受了SFM.
- 要强调不同UEA之间的交叉敏感化潜力.
- 强调为UEA严重不良反应做好准备的重要性.
主要方法:
- 一个62岁的男性患者的病例报告.
- 患者经历了立即的过敏反应,在SFM给药后,无脉冲的电活动停止.
- 诊断证实了三酶水平的升高,这表明巨细胞的激活.
主要成果:
- 患者在施用SFM后出现了危及生命的过敏反应和心脏骤停.
- 自发循环的恢复是在复苏后2分钟内实现的.
- 升高的酸酶水平证实了全身性巨细胞的激活.
结论:
- 这是第一个报告的SFM诱导的过敏反应导致心脏骤停的病例,该病例发生在患有PLM过敏症的患者身上.
- 临床医生必须意识到不同UEA之间的潜在交叉敏感性.
- 在使用UEA时,即时获得复苏设备和专业知识至关重要,特别是在高危患者中.
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