在患有慢性轻度创伤性脑损伤的退伍军人中,眼动控制和认知功能.
Jeffrey R Hebert1, Brandie D Wagner, Christopher M Filley
1Marcus Institute for Brain Health (JRH, CMF, KLC, DR, CHJ-B, AVM, PSS), University of Colorado School of Medicine, Aurora, Colorado; Department of Physical Medicine & Rehabilitation (JRH, CHJ-B), University of Colorado School of Medicine, Aurora, Colorado; Department of Biostatistics & Informatics (BDW), University of Colorado-Colorado School of Public Health, Aurora, Colorado; Department of Neurology (CMF), Behavioral Neurology Section, University of Colorado School of Medicine, Aurora, Colorado; Department of Family Medicine (KLC), University of Colorado School of Medicine, Aurora, Colorado; Department of Neurology (DR, AVM, PSS), University of Colorado School of Medicine, Aurora, Colorado; Department of Radiology (DR, RK), University of Colorado School of Medicine, Aurora, Colorado; Department of Ophthalmology (SMM, PSS), University of Colorado School of Medicine, Aurora, Colorado; Department of Neurosurgery (PSS), University of Colorado School of Medicine, Aurora, Colorado; and Division of Ophthalmology (Department of Surgery) (PSS), Uniformed Services University of the Health Sciences, Bethesda, Maryland.
经过轻度创伤性脑损伤 (mTBI) 的退伍军人在受伤后多年表现出持续的眼部运动控制 (OMC) 和认知缺陷. 这些问题,包括注意力受损和眼动控制,在慢性mTBI患者中是可以检测到的.
科学领域:
- 神经科学是一个神经科学.
- 创伤性脑损伤研究研究
- 眼科医生 眼科 眼科
背景情况:
- 轻度创伤性脑损伤 (mTBI) 经常导致服务人员的持续眼动控制 (OMC) 和认知功能障碍.
- 这些缺陷可能是微妙的,只有在压力下才会表现出来,在初始损伤后很长一段时间就会使诊断复杂化.
- 对于慢性mTBI中OMC和认知功能之间的关系的了解有限.
研究的目的:
- 调查眼睛运动控制 (OMC) 与老兵慢性轻度创伤性脑损伤 (mTBI) 的认知功能障碍之间的持久关系.
- 确定能够在慢性mTBI人群中检测这些同时出现的缺陷的临床工具.
- 在mTBI的慢性阶段探索潜在的OMC认知轴.
主要方法:
- 一个横截面的观察性研究,将军人与慢性mTBI (n=38) 与对照 (n=40) 的军事退伍军人进行比较.
- 使用计算机化King-Devick (K-D) 测试,用于反动任务的眼睛跟踪,康纳斯的持续性能测试 (CPT) 和FAS口语流利性测试.
- 使用DSM-5 (PCL-5) 的PTSD检查清单评估创伤后压力症状.
主要成果:
- 与对照组相比,患有慢性mTBI的退伍军人在K-D测试中表现出明显更多的错误和更长的完成时间.
- 在mTBI组中,在各种范式中观察到增加的反相应延迟和错误率.
- 此外,mTBI组的PCL-5分数更高,FAS测试表现更差,CPT错误更多,并发现了创伤后的时间和特定的OMC错误之间的相关性.
结论:
- 眼动控制 (OMC) 和认知性能缺陷是慢性轻度创伤性脑损伤 (mTBI) 的退伍军人持续存在的,同时发生的问题.
- 这些缺陷即使在受伤11年后也可以检测到,这表明慢性mTBI中存在OMC认知轴.
- 确定了OMC任务的认知相关性,有助于对慢性mTBI评估的临床解释.
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