在患有直肠癌的患者中,AXL和C-MET的预后和预测值
Carmen Austrália Paredes Marcondes Ribas1, Efstathia N Doelken2, Sudipta Tripathi3
1Faculdade Evangélica Mackenzie do Paraná - Curitiba (PR), Brazil.
概括
研究直肠癌生物标志物AXL和C-MET显示,可溶性C-MET水平可以预测新辅助化疗后的治疗反应,而AXL显示与健康受试者的差异.
科学领域:
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
- 分子诊断学 分子诊断
背景情况:
- 结直肠癌在预后和治疗监测方面存在重大挑战.
- 在直肠癌的新辅助和辅助疗法中,急需可靠的生物标志物.
研究的目的:
- 评估AXL和C-MET作为癌症干细胞在直肠癌中的生物标志物.
- 为了将这些生物标志物与临床病理特征和新辅助化学放射治疗后的结果相关联.
主要方法:
- 在164名直肠癌患者中,回顾性分析可溶性AXL和C-MET的血清水平.
- 对原发性瘤组织进行了免疫光分析.
主要成果:
- AXL血清水平与健康对照人群有显著差异,但与瘤阶段或存活率无关.
- 瘤组织AXL和C-MET的表达随着阶段的增加而增加;C-MET在大多数患者中显示出升高的水平,特别是在治疗后.
- 升高的C-MET水平显示,对新辅助疗法的反应较差的趋势不显著 (p=0.074).
结论:
- 在新辅助/辅助治疗期间或之后,AXL血清水平对直肠癌没有预后.
- 受新辅助化学放射治疗影响的可溶C-MET显示出作为直肠癌治疗反应预测标志物的潜力.
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