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通过通过一种新型的Lactiplantibacillus plantarum C4菌株改善肠道屏障功能来治疗IBD
Ahmed Samir1, Amira Abdeldaim2
1Biochemistry Department, October University for Modern Sciences and Arts, Faculty of pharmacy, Giza, 12451, Egypt. samiraboelnoor@gmail.com.
一种新的Lactiplantibacillus益生菌菌株通过减少炎症和氧化应激,有效地控制结肠炎. 这种有前途的治疗方法可以加强肠道屏障,为炎症性肠病 (IBD) 患者提供安全的替代方案.
科学领域:
- 胃肠道学和微生物学
- 免疫学和炎症研究研究
- 药物发现和开发 药物发现和开发
背景情况:
- 炎症性肠病 (IBD) 是一种慢性疾病,严重影响患者的生活质量.
- 目前的IBD治疗有局限性,需要探索更安全的长期治疗策略.
- 肠道微生物群失生症在IBD的发病过程中起着至关重要的作用,强调益生菌作为潜在的干预措施.
研究的目的:
- 评估一种新型Lactiplantibacillus菌株在治疗小鼠中德克斯硫酸盐 (DSS) 诱导的大肠炎的疗效.
- 为了比较新型益生菌菌株与商业益生菌和硫素的治疗效果.
- 调查新型Lactiplantibacillus菌株对炎症标志物,氧化应激和肠道屏障功能的影响.
主要方法:
- 在小鼠中使用DSS诱导大肠炎,然后用新型的Lactiplantibacillus菌株,一种商业益生菌或硫沙拉治疗.
- 量化了炎症标记物 (IL-6,IL1-β,TNF-α),氧化应激标记物 (甲酶,SOD,MDA) 和紧结蛋白表达物 (克劳丁1,奥克卢丁,ZO-1).
- 实验在体内 (小鼠结肠) 和体外 (CaCo2细胞系) 进行,以评估菌株的影响.
主要成果:
- 这种新型的Lactiplantibacillus菌株显著降低了促炎性细胞因子水平和氧化应激标志物.
- 用新型菌株治疗导致紧结蛋白的表达增加,这表明肠道屏障完整性得到了增强.
- 新型Lactiplantibacillus菌株的疗效与硫法萨拉相提并论,性能优于商业化益生菌制剂.
结论:
- 新型的Lactiplantibacillus菌株在治疗大肠炎方面表现出显著的治疗潜力.
- 这种益生菌有效地减轻炎症,减少氧化应激,并加强肠道屏障.
- 这些发现支持这种Lactiplantibacillus菌株的发展,作为炎症性肠病的有前途,安全和有效治疗方法.
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