在过敏反应后维持牛酸治疗:与脱敏方案的现实世界经验
Eleftherios Christodoulis1, Panagiotis J Vlachostergios2,3, Jacqueline Connell1
1Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.
Clinical and experimental medicine
|January 21, 2026
概括
奥克萨利普拉丁脱敏方案使大多数患有过敏反应 (HSR) 的患者能够继续化疗. 这种方法使83%的患者能够以可接受的瘤结果完成治疗.
科学领域:
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 对氧沙的过敏反应 (HSR) 影响7-25%的患者,这对继续治疗构成了挑战.
- 尽管证据有限,但药物脱敏方案 (DDP) 仍在使用,为受益于oxaliplatin的患者提供了潜在的解决方案.
研究的目的:
- 在第三级癌症中心评估oxaliplatin脱敏的可行性和结果.
- 评估oxaliplatin脱敏症患者的HSR复发率和治疗完成率.
主要方法:
- 对66名患有胃肠道恶性瘤的患者进行了回顾性观察性研究,这些患者接受了带有DDP的氧沙类化疗.
- 对临床病理学特征,瘤学结果,HSR复发和治疗完成的分析.
主要成果:
- 大多数患者 (53%的结肠直肠,39%的上部肠道) 接受了氧沙脱敏治疗,主要是有缓解意图 (85%).
- 83%的患者成功完成了预期的治疗,其中76%的患者继续原始治疗而不进行修改.
- 16%的人经历了复发的HSR,但整体瘤结果是可以接受的,包括治疗反应和疾病稳定.
结论:
- 氧化脱敏是一种可行的策略,用于管理符合条件的患者的HSR.
- 该协议允许继续获得有效的化疗,保持可接受的瘤治疗结果和低停药率.
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