一个多标记面板用于诊断和预测真菌感染的预后
Yunyan Lou1, Fanghao Yu1, Yanting Zhao1
1Department of Clinical Laboratory, Yiwu Central Hospital, Yiwu, 322000, China.
Clinical and experimental medicine
|January 21, 2026
概括
一个新的多标记面板有效地诊断真菌感染 (FI),并预测患者的结果. 这种可访问的工具集成了常规生物标志物,以改善临床决策,特别是在资源有限的环境中.
科学领域:
- 医学诊断 医学诊断 医学诊断
- 生物标志物发现发现
- 传染病研究 传染病研究
背景情况:
- 真菌感染 (FI) 带来了重大的诊断挑战.
- 准确的诊断和预后分层对于有效的患者管理至关重要.
- 现有的诊断方法可能缺乏可访问性或全面的预后能力.
研究的目的:
- 开发和验证用于真菌感染诊断的常规,基于指标的多标记面板.
- 预测患有真菌感染的患者的预后.
- 创建一个可访问的诊断和预后工具,特别是在资源有限的环境中.
主要方法:
- 134名患者的回顾性队列研究,随机分为培训 (n=75) 和验证 (n=59) 组.
- 使用非参数测试和逻辑回归对差异指标进行选,用于变量选择使用LASSO回归.
- 通过5倍交叉验证对四个机器学习算法 (逻辑回归,SVM,GNB,LightGBM) 的比较,验证了最佳模型.
- 选择六个核心指标:hsCRP,BNP,PT%,D-Dimer,IL-17和PCT. 这些指标包括:
主要成果:
- 开发了一个基于后勤回归的多标记面板,整合了炎症,凝血和心脏生物标记.
- 验证组中的诊断性能显示AUC为0.845 (灵敏度为80.00%,特异性为72.41%).
- 验证组中的预后性能产生了0.767的AUC (灵敏度72.41%,特异性90.00%),超过单个指标的表现.
结论:
- 开发的逻辑回归衍生的多标记面板为真菌感染诊断提供了可靠和可访问的工具.
- 该小组为患有真菌感染的患者提供了有效的预后分层.
- 这种方法在资源有限的环境中对改善患者护理和治疗结果尤为有价值.
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