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与肠道微生物群相关的饮食模式及其与妇科癌症的关联:NHANES 2011-2018年

Yu'e Yang¹, Chunfang Ha²

¹The First Clinical Medical College of Ningxia Medical University, 1160 Shengli Street, Xingqing District, Yinchuan, 750000, Ningxia Hui Autonomous Region, China.

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概括

与肠道健康相关的饮食质量评分可能会降低妇科癌症 (GC) 风险. 较高的饮食诱导肠道微生物群 (DI-GM) 评分与美国女性显著较低的GC发病率有关.

科学领域:

妇科瘤学妇科瘤学
营养科学营养科学
微生物组研究微生物组研究

背景情况:

饮食诱导的肠道微生物群 (DI-GM) 评分评估了微生物健康的饮食质量.
DI-GM分数与妇科癌症 (GC) 风险之间的关系尚不清楚.

研究的目的:

检查DI-GM得分与美国女性群体患妇科癌症的风险之间的关联.

主要方法:

分析了来自美国国家健康和营养检查调查 (NHANES) 2011-2018年8,512名成年女性 (≥20岁) 的数据.
根据对肠道微生物有益或有害的14个食物组的摄入量计算DI-GM分数.
采用多变量逻辑回归模型来估计赔率比率 (OR) 和95%置信区间 (CI),并根据相关共变量进行调整.

主要成果:

与对照组相比,被诊断患有GC的女性的DI-GM平均得分明显较低 (4.7对5.0;p=0.031).
DI-GM得分的增加与GC风险降低有关 (调整后OR每单位增加:0.92;95%CI0.87-0.98;p=0.011).
与得分为0-3 (p=0.037) 的人相比,DI-GM得分≥6的个体患GC的可能性降低了27% (p=0.037). 有益的饮食成分独立与较低的GC风险相关.

结论:

对微生物群友好型饮食的更高坚持可能有助于降低女性患妇科癌症的风险.
影响肠道微生物群组成的饮食模式需要进一步研究它们在妇科癌症预防中的作用.

关键词:

饮食饮食饮食饮食妇科新生病的发生.后勤模型后勤模型微生物群中的微生物群尼汉斯 (NHANES) 是一个名人.

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