在腹腔透析患者中治疗慢性便秘的共生补充:一项意大利多中心前性研究
Gennaro Argentino1, Giuseppe Paribello2, Andrea Foderini3
1Nephrology Unit of "Ospedale del Mare" Hospital, Napoli, Italy.
概括
同生菌补充剂显著改善了便秘得分,并减少了腹膜透析患者的药使用. 这种干预提供了一种有希望的方法来管理这种脆弱人群的便秘.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 慢性便秘是经过腹膜透析 (PD) 的患者常见的并发症.
- 在PD患者中,便秘增加了导管功能障碍和腹膜炎的风险.
- 肠道失调与透析患者的便秘恶化有关.
研究的目的:
- 评估协生菌补充剂在治疗PD患者慢性便秘方面的疗效.
- 评估协生菌对便秘严重程度和药依赖性的影响.
主要方法:
- 一项前性单臂研究在16周内进行.
- 参与者接受了含有果糖-寡糖和特定益生菌菌株 (Lactobacillus casei,Lactobacillus rhamnosus,Lactobacillus reuteri,Saccharomyces boulardii) 的协生补充剂.
- 主要终点包括便秘评分系统的变化和药的使用.
主要成果:
- 在76名便秘患者中,有70人完成了为期16周的研究.
- 同生菌补充剂导致便秘得分显著降低 (平均变化 -5.3;P = .001).
- 相当一部分的药使用者 (36.8%暂停使用,42.1%减少使用) 经历了对药的依赖减少.
结论:
- 同生菌补充剂有效地缓解PD患者的慢性便秘.
- 这种干预可以显著减少对药的使用需求.
- 协生菌的益处在各种患者人口统计和临床特征中是一致的.
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