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素对严重败血症器官功能障碍和死亡率的影响
Islam Abdelaal Abdelmouty Taher1, Farouk Kamal Eldin1, M A Wareth Eissa1
1Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
PloS one
|January 21, 2026
概括
在严重的败血症患者中,素治疗减少了血管压缩剂和炎症标志物的需要,并缩短了ICU停留时间. 然而,它对28天死亡率的影响需要进一步研究.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 败血症是一种危及生命的疾病,在ICU中死亡率高.
- 对感染的失调宿主反应是败血症的特征.
- 作为一种选择性血清素再吸收抑制剂的素,在败血症中显示出潜在的免疫代谢益处.
研究的目的:
- 为了评估fluoxetine对严重败血症中血管压缩剂持续时间的影响.
- 评估素对器官功能障碍和炎症标志物的影响.
- 为了确定fluoxetine对严重败血症患者死亡率的影响.
主要方法:
- 进行了一项单中心,随机,双盲,安慰剂控制的试验.
- 46名严重败血症患者接受了西 (40毫克/天) 或安慰剂以及标准治疗.
- 主要结局是血管压缩剂持续时间;次要结局包括SOFA得分,炎症标志物,ICU停留和死亡率.
主要成果:
- 素显著减少了血管压缩剂的持续时间 (p < 0.001) 和ICU停留时间 (p = 0.005).
- 炎症标志物 (TNF-α,IL-1,CRP,前素) 在第7天减少 (p <0.05).
- SOFA和APACHE II分数较低;28天死亡率没有显著差异.
结论:
- 辅助的西可以降低严重败血症的血管压缩剂依赖性和炎症.
- 素可能会缩短ICU停留时间,但没有副作用.
- 在败血症中使用fluoxetine对死亡率的益处需要进一步研究.
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