选择性微创性结直肠手术 (CIMICS) 后的连续伤口透与安慰剂相比:随机对照试验的研究协议
Sofie Glazemakers1,2, Stijn H J Ketelaers1, Harm J Scholten3
1Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands.
PloS one
|January 21, 2026
概括
这项研究评估了用局部止痛药持续伤口透 (CWI) 作为微创性结直肠外科手术后增强恢复 (ERAS) 护理的一部分. 这些发现可能会增强多模式止痛和术后指导方针.
科学领域:
- 麻醉学 麻醉学
- 术后恢复 术后恢复
- 疼痛管理 疼痛管理
背景情况:
- 手术后增强恢复 (ERAS) 计划利用多模式止痛药来减少阿片类药物的使用并改善患者的治疗结果.
- 使用局部止痛药的持续伤口透 (CWI) 是多模式止痛药的潜在补充.
- 在ERAS协议中,CWI在微创手术中的有效性尚未得到充分证实.
研究的目的:
- 调查是否将CWI添加到标准ERAS护理中可以提高接受微创结直肠手术的患者的术后恢复.
- 评估CWI对患者报告结果和临床康复里程碑的影响.
主要方法:
- 一个单中心,盲目的,随机对照试验,涉及192名患者.
- 患者在标准化ERAS护理的同时,接受了bupivacaine的CWI或用盐水的安慰剂CWI.
- 主要结局是术后第二天的康复质量-15分 (QoR-15NL).
主要成果:
- 这一部分应在试验结果可用后填写.
- 该研究旨在比较QoR-15NL,疼痛评分,阿片类药物消费,住院,功能恢复和CWI和安慰剂组之间的并发症率.
结论:
- 这项试验代表了CWI在最少侵入性,ERAS-坚持性结直肠外科手术中的第一个随机对照评估.
- 预计结果将为基于证据的外科手术期间护理指南提供信息,并优化多模式止痛策略.
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