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Updated: Jan 23, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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一个向细胞因子受体的嵌合体工具箱,用于扩大细胞外向蛋白质降解的范围

Kaan Kumru1, Zi Yao1, Brandon B Holmes2,3

  • 1Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158.

Proceedings of the National Academy of Sciences of the United States of America
|January 21, 2026
PubMed
概括

研究人员扩展了细胞因子受体向奇默体 (kineTAC) 工具箱用于细胞外向蛋白降解 (eTPD). 这一新工具包能够在特定的细胞和组织中精确降解蛋白质,从而增强治疗潜力.

关键词:
抗体是对抗体的重要组成部分.细胞因子 细胞因子接收器回收回收的使用方法有针对性的蛋白质降解降解.

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