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Updated: Jan 23, 2026

Fluorescence-Based Detection of FEN1 Nuclease Activity and Screening of Small-Molecule Inhibitors
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Fluorescence-Based Detection of FEN1 Nuclease Activity and Screening of Small-Molecule Inhibitors

Published on: June 27, 2025

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一种使用线粒体向小分子干和临床抑制剂对抗黑色素瘤的新组合疗法

Ka-Hin Chan1, Bo-Xin Zheng1, Yingying Zheng1

  • 1Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hung Hom, Hong Kong SAR 999077, P.R. China.

ACS chemical biology
|January 21, 2026
PubMed
概括

研究人员开发了新的线粒体向分子,以稳定黑色素瘤细胞中的线粒体DNAG-四重复合体 (G4s). 该化合物B1N有效地破坏了癌细胞代谢,并且当与Vemurafenib结合时,显示出协同作用的抗癌效应.

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